there is an pretty old note about a similar error ([CPIC return code 020, SAP return code 223|https://websmp102.sap-ag.de/~form/handler?_APP=01100107900000000342&_EVENT=REDIR&_NNUM=512272&_NLANG=EN]). It was related to a BEX Patch. May be you should raise a note at the service market place for your issue.
This is a "Time out when establishing connection" error.
Please, verify RFC connection between the systems, remote user password, etc. Also check the value defined in the system profile for RFC connection time out. Ask your Basis Team to help you with this.
SAP Note 63347 lists all CPIC error codes. It also includes some reference notes at the bottom that might help you.
Hope this helps.